An investigation of a supersonic chemical reactor.

Thesis (Ph.D.)-University of Natal, Durban, 1977.The development of a supersonic chemical reactor is examined. The central concept of such a reactor is that gases can be expanded to supersonic speed which will result in a decrease in their static temperature to the extent that no reaction will occur when the gases are mixed together. After mixing has occurred the mixture can then be passed through a standing shock to raise this temperature very rapidly, thus controlling the product spectrum. The main areas of interest for such a reactor, namely the establishment of a shock and the mixing of two gases at supersonic speed are examined

Automatic Recognition of Light Microscope Pollen Images

This paper is a progress report on a project aimed at the realization of a low-cost, automatic, trainable system "AutoStage" for recognition and counting of pollen. Previous work on image feature selection and classification has been extended by design and integration of an XY stage to allow slides to be scanned, an auto focus system, and segmentation software. The results of a series of classification tests are reported, and verified by comparison with classification performance by expert palynologists. A number of technical issues are addressed, including pollen slide preparation and slide sampling protocols

Relationship between impaired BMP signalling and clinical risk factors at early-stage vascular injury in the preterm infant.

Peer reviewed: TrueAcknowledgements: We sincerely thank the patients and their families of the AIRR study cohort for their significant contribution to the study by providing the samples.INTRODUCTION: Chronic lung disease, that is, bronchopulmonary dysplasia (BPD) is the most common complication in preterm infants and develops as a consequence of the misguided formation of the gas-exchange area undergoing prenatal and postnatal injury. Subsequent vascular disease and its progression into pulmonary arterial hypertension critically determines long-term outcome in the BPD infant but lacks identification of early, disease-defining changes. METHODS: We link impaired bone morphogenetic protein (BMP) signalling to the earliest onset of vascular pathology in the human preterm lung and delineate the specific effects of the most prevalent prenatal and postnatal clinical risk factors for lung injury mimicking clinically relevant conditions in a multilayered animal model using wild-type and transgenic neonatal mice. RESULTS: We demonstrate (1) the significant reduction in BMP receptor 2 (BMPR2) expression at the onset of vascular pathology in the lung of preterm infants, later mirrored by reduced plasma BMP protein levels in infants with developing BPD, (2) the rapid impairment (and persistent change) of BMPR2 signalling on postnatal exposure to hyperoxia and mechanical ventilation, aggravated by prenatal cigarette smoke in a preclinical mouse model and (3) a link to defective alveolar septation and matrix remodelling through platelet derived growth factor-receptor alpha deficiency. In a treatment approach, we partially reversed vascular pathology by BMPR2-targeted treatment with FK506 in vitro and in vivo. CONCLUSION: We identified impaired BMP signalling as a hallmark of early vascular disease in the injured neonatal lung while outlining its promising potential as a future biomarker or therapeutic target in this growing, high-risk patient population